I-Argipressin CAS: 113-79-1 AVP BETA-HYPOPHAMINE

[Arg8] -Isixazululo se-Vasopressin sasetshenziswa njenge-antigen yokulungiselela i-preadsorbed antisera ye-immunocytochemistry.Umkhiqizo usetshenziswe kusiko leseli le-L6 le-C5 subclone ezifundweni zokuhlukanisa.

Ngenxa yokuthi izinzile, i-desmopressin ikhethwa ekwelashweni ikakhulukazi uma imiphumela yokucindezela ingafunwa.Inkomba eyinhloko yokwelapha isifo sikashukela i-insipidus esimaphakathi, isifo esiba khona lapho ukukhiqizwa kwe-ADH kuncipha futhi kubonakala nge-polydipsia, i-polyuria, nokuphelelwa amanzi emzimbeni.I-Desmopressin iphinde isetshenziselwe ukunciphisa i-enuresis eyinhloko yasebusuku, noma ukuchama embhedeni, ezinganeni.Iwusizo kubantu abane-hemophilia A emaphakathi noma abanezinhlobo ezithile zesifo sika-von Willebrand, lapho i-von Willebrand factor ikhona emazingeni aphansi.Kulezi zimo, i-desmopressin inikezwa lapho ukopha kakhulu noma ngaphambi kokuhlinzwa ukuze kuncishiswe ukopha ngokungaqondile ngokwandisa amanani ezinto ezihlanganayo.Umthelela omubi ongaba khona we-desmopressin ukudakwa kwamanzi uma kuthathwa kakhulu.
Abaphikisi be-ADH, okuhlanganisa ama-analogue angewona ama-peptide angase athathwe ngomlomo, athuthukiswe ngokucaciswa kwezinhlobo zama-receptors ngamunye.Esikhathini esizayo, lezo ezivimba ama-V1 receptors zingase zibe usizo ekwelapheni umfutho wegazi ophakeme, futhi lawo avimba ama-V2 receptors angase abe usizo kunoma yisiphi isimo sokugcinwa kwamanzi ngokweqile noma i-hyponatremia, okungekho kuze kube manje ukwelashwa okwanelisayo okwanelisayo.