I-Human Choroinic Gonadotrophin HCG CAS:9002-61-3

I-chorionic gonadotropin yomuntu (hCG) iyihomoni ye-glycoprotein ekhishwa amaseli e-placental endodermal.Umsebenzi wayo oyinhloko ukuvuselela i-corpus luteum, ekhuthaza ukukhishwa okuqhubekayo kwe-estrogen ne-progesterone, ukuze kuthuthukiswe ukwakheka kwesibeletho esinqunyiwe futhi senze i-placenta ikhule futhi ivuthwe.Ngokushesha nje lapho umbungu usufakiwe, amangqamuzana e-blastoderm aqala ukukhiqiza i-hCG, ngakho ukukhulelwa kunganqunywa amazinga e-hCG egazini noma emchameni.

Yakhiwa izinsalela ze-amino acid ezingama-244, enesisindo samangqamuzana angama-36.7kDa nosayizi we-7.5 × 3.5 × 3 nm.Kuyi-heterodimer ene-α subunit efanayo ne-luteinizing hormone (LH), i-follicle-stimulating hormone (FSH) ne-thyrotropin (TSH), kodwa i-β subunit ehlukile.I-subunit ye-α yayiqukethe izinsalela ze-amino acid ezingu-92, futhi i-β subunit iqukethe izinsalela ze-amino acid ezingu-145.

Ukuhlanganiswa kwe-hCG kwabesifazane kwanda kakhulu ngemva kokukhulelwa, futhi ukuba khona kwe-hCG ku-plasma nomchamo kungenye yezibonakaliso zokuqala zokukhulelwa futhi isetshenziselwa ukuhlolwa kokukhulelwa.

(1) Inomsebenzi we-FSH ne-LH ukugcina ubude besikhathi se-corpus luteum yokuya esikhathini nokwenza i-corpus luteum yokuya esikhathini ibe yi-gestational corpus luteum;

(2) Khuthaza ukuphunga kwe-androgens ku-estrogen, futhi kukhuthaze ukwakheka kwe-progesterone;

(3) Ukuvimbela umphumela wokuvuselela wesitshalo i-lectin kuma-lymphocyte, i-chorionic gonadotropin yomuntu ingakhangiswa ebusweni bamaseli e-trophoblast, ukuze kugwenywe ukuhlaselwa kwamaseli e-embryonic trophoblast ngama-lymphocyte kamama;

(4) Ukusebenza kwe-LH, ngaphambi kokuba i-pituitary ye-fetus ikhiphe i-LH, ishukumisa i-fetus testis ukuthi ikhiphe i-testosterone ukuze ikhuthaze ukuhlukana kobulili besilisa;Ingakwazi futhi ukukhuthaza ukuthuthukiswa kwe-gonadal, owesilisa angashukumisa ubungqabavu be-testis mesenchymal cell, andise secretion of male hormone (testosterone).Kubaluleke kakhulu ekwelapheni iziguli zesilisa ezinokukhubazeka okuhlangene kwe-pituitary, okungakwazi nje ukukhuthaza ukuthuthukiswa kwe-gonad kanye nokuphuma kwe-hormone yesilisa, kodwa futhi kukhuthaze ukuthuthukiswa kwezici zesibili zobulili.

(5) Ingakwazi ukubophezela kumamukeli we-TSH wamangqamuzana e-thyroid yomama futhi ikhuthaze umsebenzi we-thyroid.