Inhibitor GW0742 CAS 317318-84-6 Impushana emhlophe

I-Andarine (S-4) iyinhlanganisela etholakala nge-arylpropionamide [S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide] kuqala kuchazwe nguYin et al.ukuze ube imodulator ye-androgen receptor (SARM) ekhethiwe.I-Andarine (S-4) yaboniswa izifundo ze-in vitro kanye ne-vivo njenge-agonist ephumelelayo ye-anabolic, ngaphandle kwemiphumela emibi evame ukuhlotshaniswa ne-anabolic-androgenic steroids, ehlobene ngokuyinhloko ne-substrate affinity ye-5α-reductase ukukhiqiza i-DHT ku-prostate.
Umsebenzi we-andarine we-pharmacological uphakamisa amandla amakhulu e-andarine ekuthuthukiseni ama-SARM atholakalayo emtholampilo, ahlinzeka ngezinzuzo eziyingqayizivele zokwelapha ngaphezu kozakwabo be-steroidal kanye nethuba elijabulisayo lokulawula ngokuhlukile imiphumela ye-androgen ezicutshini ezihlukahlukene ezihlosiwe, ngaleyo ndlela kuncishiswe ukuphazamiseka kokujwayelekile. .Ngakho-ke, i-atarine inesithembiso esivivinyweni esithuthukisiwe somtholampilo esihlose ukwelapha izifo ezihlobene neminyaka kanye nokulwa nezimpawu zezifo ezinzima ezifana ne-sarcopenia kanye ne-cachexia yomdlavuza.
I-Andarine iyi-agonist ekhethiwe ye-nonsteroidal androgen receptor (AR) ene-Ki ye-4 nM.I-Andarine ibonisa umsebenzi we-anabolic onamandla futhi osebenzayo futhi iphumela ekukhuthazeni okuncike kumthamo wokukhula kwe-prostate, ama-seminal vesicles, ngokulandelana.I-Andarine inezici ezingaba yi-antiosteoporotic.
I-Andarine (phambilini eyayaziwa ngokuthi i-GTx-007; S-4; GTx007; S4) iyi-agonist yomlomo esebenzayo futhi ekhethiwe engeyona i-steroidal androgen receptor (AR), ikakhulukazi i-elective androgen receptor modulator (SARM), ewusizo olukhulu ekumosheni kwemisipha. kanye ne-osteoporosis.Ivula i-AR nge-Ki ye-4 nM futhi ikhetha izicubu ezithweni ze-anabolic.I-Andarine iyaphenywa ukuze yelaphe izimo ezinjengokonakala kwemisipha, ukukhumuzeka kwamathambo kanye ne-benign prostatic hypertrophy.Kumodeli yezilwane ye-benign prostatic hypertrophy, i-andarine yaboniswa ukunciphisa isisindo se-prostate ngokusebenza okufanayo kwe-finasteride, kodwa ngaphandle kokukhiqiza noma yikuphi ukuncipha kwesisindo somzimba noma imiphumela emibi ephikisana ne-androgenic.