I-Ipamorelin CAS: 170851-70-4 IPAMORELIN;AIB-HIS-D-NAL(2)-D-PHE-LYS-NH2
Ukusetshenziswa
I-Ipamorelin (INN) (ikhodi yokuthuthukisa i-NNC 26-0161) i-agonist ekhetha i-peptide ye-auxin ekhulula ama-peptides/somatosecretin receptors (GHS) kanye ne-somatosecretin.I-pentapeptide ene-amino acid ukulandelana kwe-Aib-His-D-2-Nal - D-Phe -Lys-NH 2, etholakala ku-GHRP-1.
I-Ipamorelin yandisa kakhulu amazinga e-plasma okukhula kwe-hormone (GH) ezilwaneni nakubantu.Ngaphezu kwalokho, i-ipamorelin ikhuthaze ukuzuza kwesisindo ezilwaneni.Njenge-pralmorelin ne-GHRP-6, i-ipamorelin ayithinti i-prolactin, i-follicle-stimulating hormone (FSH), i-luteinizing hormone (LH), noma amazinga we-thyrotropin (TSH).Kodwa-ke, ngokungafani ne-pramoline (GHRP-2) ne-GHRP-6, kodwa efana ne-hormone yokukhula ekhulula i-hormone (GHRH), i-iparerelin ayikhuthazi ukukhishwa kwehomoni ye-adrenocorticotropic (ACTH) noma i-cortisol futhi ikhetha kakhulu ukwehlisa ukukhishwa kwe-GH kuphela.
I-Ipamorelin ekuqaleni yasungulwa nguNovo Nordisk futhi yenza ukuhlolwa kwemitholampilo yesigaba II ngokwayo njengendlela yokwelapha ilobstruction yangemva kokuhlinzwa, kodwa yayekwa ngenxa yokuntuleka kokuphumelela.
I-Ipamorelin isetshenziswe abasubathi njengesidakamizwa esithuthukisa ukusebenza.