I-Nimetazepam CAS: 2011-67-8 i-hypnotic tranquilizer

I-Nimetazepam iyi-hypnotic esebenzayo ephakathi, i-benzodiazepine derivative.Yaqala ukuhlanganiswa ngo-1964 yiqembu likaHoffmann-La Roche.Ine-hypnotic enamandla, anti-ukukhathazeka, ukuthulisa kanye nemiphumela yokuphumula kwemisipha yamathambo.I-Nimetazepam nayo iyi-anticonvulsant ephumelela kakhulu.Ithengiswa njengethebhulethi engu-5-milligram ebizwa ngokuthi i-Erimin, igama lomkhiqizo elenziwe futhi lathengiswa yi-Sumitomo, inkampani enkulu yaseJapane.I-Japan ukuphela kwezwe emhlabeni elikhiqiza i-nimetazepam.Ngaphandle kwaseJapane, i-Erimin itholakala ezindaweni eziningi zaseMpumalanga naseNingizimu-mpumalanga ye-Asia futhi isetshenziswa kabanzi njengokwelashwa kwesikhashana kubantu abanokuqwasha okukhulu abakuthola kunzima ukulala noma ukulala.I-Sumitomo iyekile ukwenza i-Erimin kusukela ngoNovemba 2015. Isatholakala njengejenerikhi noma i-Lavol.

I-Nimetazepam yayinqunywe kabanzi ngeminyaka yawo-1980 kanye nawo-1990, ikakhulukazi eJapane, eMalaysia, eBrunei, ePhilippines, eThailand, e-Indonesia, eHong Kong naseSingapore.Ngokuxhashazwa nokulutheka kudlangile, imiyalelo yesidakamizwa yehle kakhulu kusukela ngo-2005. Isetshenziswa ngokuyinhloko njenge-anticonvulsant ezinganeni.Iphinde isasetshenziswa ezimeni ezinzima kakhulu nezithena amandla zokuqwasha Ezigulini ezilaliswe esibhedlela noma ukwelashwa kwesikhashana esifushane.Ngale njongo, amaphilisi okulala i-benzodiazepines Esazolam ne-nitrazepam asetshenziswe kaningi kune-nitrazepam.Ama-antidepressants afana ne-trazodone ne-mirtazapine noma i-Zopiclone ne-zolpidem imithi yokuqala yokuqwasha.

Nakuba incwadi kadokotela ye-nimetazepam yehlile, ukusetshenziswa kabi kwesidakamizwa kuhlala kuphezulu eBrunei, eSingapore, eMalaysia nasePhilippines.Ivamise ukusetshenziswa ekuhlanganisweni ne-methamphetamine ne-ecstasy, kanye nama-opioid (ikakhulukazi i-heroin noma i-morphine).I-Nimetazepam ingaphansi kwemikhawulo eqinile yezomthetho eMalaysia, eyenze umuthi wantuleka, kodwa amaphilisi amaningi athengiswa emakethe emnyama ngaphansi kwegama elithi Nimetazepam angawomgunyathi.I-Diazepam ne-nitrazepam aphakathi kwama-benzodiazepines asetshenziswa kakhulu esifundeni, futhi ngenxa yalokho, avame ukuphambukiswa futhi athengiswe emakethe emnyama, ngokuvamile njenge-nitrazepam.

Ukukhiqizwa okungekho emthethweni kwe-Nimezepam (ethengiswa njenge-Erimin-5) kugcwele esifundeni.Ukuhlukunyezwa kwe-nimetazepam kwaqhubeka ukwanda ngawo wonke ama-2010.Ukubanjwa kwamaphilisi e-Erimin-5 enziwe ngokungekho emthethweni kwaqondana nokubanjwa kwe-methamphetamine e-Malaysia.Inani elincane lamaphilisi e-Erimin-5 angekho emthethweni angu-46 ashaqwe ahlolelwa izindawo zawo ezibonakalayo namakhemikhali.Isithako esisebenzayo, i-dopant, i-diluent eyinhloko, kanye nodayi kuhlanganisa izici zamakhemikhali zethebhulethi.Imiphumela yabonisa ukuthi i-Nimetazepam yayiyisithako esisebenzayo esivame kakhulu kumaphilisi amaningi ashaqiwe.I-lactose itholwe njenge-diluent eyinhloko kumasampuli amaningi, ilandelwa yi-mannitol kwase kuba yi-dicalcium phosphate dihydrate.Ukushona kwelanga okuphuzi kwatholakala kumasampula amaningi amaphilisi, asetshenziswa ewodwa noma ahlanganiswe nabanye odayi (isb. i-tartar ne-Lichenol 4R) ukunikeza iphilisi umbala wepentshisi/wolintshi.Amaphilisi aluhlaza kusampula aqukethe odayi abaluhlaza okwesibhakabhaka nobetartar.I-Diazepam iwumuthi wokulwa nokukhathazeka futhi iyisithako esisebenzayo kwelinye lamaphilisi angama-46.I-Nitrazepam, i-sedative enamandla ne-hypnotic kanye nomuthi ongumzali we-nitrazepam, itholwe iyinhlanganisela yesibili, i-caffeine iyisakhi esiyinhloko esihlanganiswe kumaphilisi amathathu.

Ngo-2003, iSingapore yashaqa amaphilisi e-Erimin-5 angu-94,200.Ilabhorethri yeCentral Narcotics Board (CNB) yenze izivivinyo kumaphilisi futhi imiphumela yaqinisekisa ukuthi ayeyi-nitrazepam ngempela.