I-Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium Salt

SEBENZISA

I-Tianeptine sodium salt iyi-antidepressant ye-tricyclic, futhi indlela yayo ye-antidepressant ihlukile kuma-antidepressants e-tricyclic endabuko.Ingakwazi ukwandisa ukuphindwa kabusha kwe-5-HT endaweni ye-synaptic, futhi ingase ibe nomthelela wokuthuthukisa ukuqhutshwa kwe-5-HT neurons.Akukho ukuhambisana kwe-choline noma i-adrenaline receptors.Ukusebenza kwe-antidepressant kufana ne-tricyclic, kodwa ukubekezelelana kungcono kune-tricyclic.Ekuhlolweni kwezilwane, kungakhuphula umsebenzi ozenzakalelayo wamaseli e-pyramidal ku-hippocampus futhi kusheshise ukululama kwawo ngemva kokuvinjwa komsebenzi.I-Chemicalbook ikhulise ukumuncwa kabusha kwe-serotonin ngama-neurons ku-cerebral cortex ne-hippocampus.Ukumuncwa kwe-tineptine sodium emgudwini wokugaya ukudla kuyashesha futhi kuphelele.Ukusabalalisa okusheshayo, i-PPB kufika ku-94%.I-metabolized ngokuphelele esibindini nge-β-oxidation ne-N-demethylation, futhi ukucaciswa kwe-T1 / 2 ye-terminal kwakufushane ku-2.5h.Inani elincane kakhulu lomuthi (8%) lakhishwa ezinso, ikakhulukazi ama-metabolites awo emchameni.Iziguli ezinokwehluleka kwezinso zasusa i-T1/2 isikhathi esinwetshiwe esingu-1.